PD Dr. Christopher R. Pryce

Preclinical Laboratory for Translational Research into Affective Disorders (PLaTRAD) Psychiatric University Hospital Zurich
August Forel-Strasse 7
8008 Zürich
Tel. +41 44 634 89 21


Christopher R. Pryce

Main goals, keywords

Animal models of emotional-motivational-cognitive states (behaviour, physiology, neurobiology) in affective disorders; Gene-environment interaction in the development and aetiology of affective disorders. Pathophysiological processes underlying psychopathology; Target discovery and neuropsychopharmacology for affective disorders; Translational research in the affective disorders; "Stress-related psychiatric disorders"; "Brain-body interface", "Neuronal-Glial interface".

Representative publications

Pryce CR, Azzinnari D, Sigrist H, Gschwind T, Lesch KP, Seifritz E
Establishing a learned-helplessness effect paradigm in C57BL/6 mice: behavioural evidence for emotional, motivational and cognitive effects of aversive uncontrollability per se
Neuropharmacology, 62(1): 358-72, 2012

Pryce CR, Azzinnari D, Spinelli S, Seifritz E, Tegethoff M, Meinlschmidt G
Helplessness: a systematic translational review of theory and evidence for its relevance to understanding and treating depression
Pharmacol Ther, 132(3): 242-67, 2011

Pryce CR, Aubert Y, Maier C, Pearce PC, Fuchs E
The developmental impact of prenatal stress, prenatal dexamethasone and postnatal social stress on physiology, behaviour and neuroanatomy of primate offspring: studies in rhesus macaque and common marmoset
Psychopharmacology (Berl), 214(1): 33-53, 2011

Pryce CR, Seifritz E
A translational research framework for enhanced validity of mouse models of psychopathological states in depression
Psychoneuroendocrinology, 36(3): 308-29, 2011

Arabadzisz D, Diaz-Heijtz R, Knuesel I, Weber E, Pilloud S, Dettling AC, Feldon J, Law AJ, Harrison PJ, Pryce CR
Primate early life stress leads to long-term mild hippocampal decreases in corticosteroid receptor expression
Biol Psychiatry, 67(11): 1106-9, 2010

Leventopoulos M, Rüedi-Bettschen D, Knuesel I, Feldon J, Pryce CR, Opacka-Juffry J
Long-term effects of early life deprivation on brain glia in Fischer rats
Brain Res, 1142: 119-26, 2007


Neuroscience Center Zurich

Preclinical Laboratory for Translational Research into Affective Disorders, UZH

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Neuroscience Center Zurich (ZNZ)